Dr Martin Henry Dawson, MD , LLB (Hon) : always about defending the underdog ?

From would-be lawyer (destined to defend the underdog) to a doctor and scientist defending the underdog ?

With no private papers available, it is hard to know for sure what really motivated pioneering medical scientist Dr (Martin) Henry Dawson, the first person to ever put DNA to work in a test tube and the first to ever inject an antibiotic (Penicillin) into a patient.

Dr Dawson, MD was actually enrolled in Arts at Dalhousie University, before the Great War changed everything.

But, from what we know of his adult personality and from his best marks in university, I would see him, if the war hadn't intervened, more as a university teacher - perhaps in history or perhaps teaching theory in law school.

Unusually for a scientist, he took no sciences courses as an undergraduate - except one in biology (where he topped his class).

His skill in German turned out to be very helpful - no great scientist before 1945 could really succeed if they couldn't read scientific German with smooth facility.

But his best courses are in areas like history, economics and philosophy.

It is important to recall he got his wartime BA degree after attending relatively few classes because he had such good marks in the few courses he did complete, before he left for the effort overseas.

Henry Dawson was far too studious to ever stop at a mere BA and then go on to teach high school - yet he never (so far as we can tell) formally enrolled in the pre-law, pre-engineering or pre-med options at Dal.

But ever loyal to his slightly older brother Howard, he might have joined him at law school but for the war.

Yet he didn't seem to have the commanding personality needed to be a successful courtroom lawyer defending the underdog.

And he certainly never ever wanted to be well off, let alone rich, as in 'rich corporate lawyer'.

But while at Dal, Dawson was busy helping teaching English to various foreign seamen at the YMCA mission to seamen, perhaps parallel to his brother Howard's similar involvement in evangelical good works.

And for what it is worth, his older brother Frank, while an engineering Dean in the American Mid West, so impressed a pioneering black engineering student with his non-prejudiced kindnesses, that the man fulsomely remembered Frank Dawson years later in his autobiography.

The entire family was not military minded but when they were needed - when poor little bleeding Belgium was betrayed by the Hun - all five boys stepped into the breach.

Belgium - again an underdog.

Henry was a (medically untrained) private in a university organized overseas military hospital at first.

Later Dawson was made an officer in the infantry and while badly wounded in the foot, still gave up his place in a stretcher for another much more wounded ordinary soldier, (an underdog) this after solving a battlefield crisis by running about on his wounded foot for ten hours.

His foot never really recovered as a result, but he received the Military Cross with citation for this selfless act.

Then at the very end of his wartime service and wounded yet again, Dawson changed his peacetime occupation from just "student" to "medical student".

His career changed - but I argue - not his urge to helping the underdog.

His lifelong concerns, as a ward doctor, were the chronically ill poor - then as now a low priority in high prestige teaching hospitals.

Underdogs of the medical world.

As a medical scientist, his interest was in the underdogs of the underdog microbes - then universally seen as primitive, primeval, weak, simple, small --- the ultimate in the living fossils.

So why then were they still here ?

If evolutionary theory was correct, Dawson wondered, shouldn't the weak and the small have long ago been vanquished by the big and the brutal ?

The microbes were once again the underdogs, the Rodney Dangerfields, of the Living World.

As a medical scientist, Dawson was particularly concerned about the harmless - hence uninteresting to other medical scientists - avirulent commensal bacteria.

Avirulent versions of 'normally' pathogenic bacteria were considered to be defective versions (of a lifeform already -see above - considered to be a living fossil).

So why then ,asked Dawson, were they still here inside us, often inside us for perhaps our entire lives -- undestroyed ?

Here is the contemporary explanation that Dawson objected to - see if you too can see its flaws in basic logic :

(1) The pneumonia bacteria can only survive in or on us - we are its only home.

(2) The normal variant of the bacteria that causes lung pneumonia and blood poisoning is deadly virulent and lives alone, floating in the blood and human intercell liquids, usually killing us (and them) in a week or two.

(3) The disease of lung pneumonia is not really contagious -- we can't really catch it from the coughing of a dying man -and remember with his death, so to die the bacteria (see #1 above).

(4) The abnormal, defective, avirulent, version harmlessly exists in tight massive colonies on the inner surfaces of our nose and throat - sometimes for our whole lives, without ever making us sick.

(5) We all have these harmless pneumonia bugs in our noses some of the time -  some of us all our lives - and when we have them, we are known as 'carriers' of these harmless commensal pneumonia bacteria.

Dawson wondered how a short life of a week or two in the lungs or blood streams of just a few of us (for even before penicillin, pneumonia bugs only killed perhaps 8% of us) could qualify as the normal form of existence for this bug.

All this, when 100% of us had the abnormal quote unquote bug in our noses for periods ranging from months and months to decades and decades ?

Haven't the normal definitions of usual and unusual been deliberately up-ended to suit an universally accepted but ultimately bizarre medical theory ?

Dawson's alternative explanation was that whether floating about alone in liquid or clinging in masses to walls, these were just normal evolutionary responses to changed niches.

If bacteria do the shapeshifting so quickly, it is not really just that they are much more plastic in the forms that they can adopt than we are capable of - it is also the simple math that a new generation to them can mean 25 minutes later not 25 years later as with us.

As a result, evolutionary response to a new crisis can happen a million times faster with them than us.

If we are honest with ourselves, an evolutionary response time like that is a big advantage and a big reason why these living fossils are still around.

Dawson spent his life tracking down the variants of bacteria that he believed demonstrated why these supposed underdogs were really Life's evolutionary topdogs.

He was the first, or among the first, to look at things like DNA-HGT,quorum sensing, molecular mimicry, CWD bacteria, biofilms and persisters.

Three quarters of a century or more later, those are still cutting edge scientific topics.

In 1940, scientific opinion was again convinced the underdog fungal slimes were incapable of making penicillin as efficiently and as cheaply as the topdog chemists of advanced human civilizations could.

Dawson disagreed - pioneering the Antibiotics Age - when he injected their 'primitive' penicillin into Aaron Alston and Charles Aronson on October 16 1940.

He was right - the topdog chemists failed totally and the underdog slime still makes all the basis of our lifesaving beta-lactam antibiotics to this very day.

When the Allied medical-political elite agreed that wartime penicillin would only go to the topdog frontline troops, Dawson characteristically objected and said all of us, dying for lack of penicillin, should receive it, war or not.

Dawson was himself dying but he gave up his life to - once again - fight for the underdog.

A life full of variations but always with that same consistency of conduct ....

Where and when was first ever intradermal penicillin sensitivity test given ?

At NYC's Columbia-Presbyterian Hospital, on  October 16th 1940.

In fact it was the historical first ever antibiotic injection given to a patient (two patients actually) followed up a few hours later, after no reaction was observed, by a larger (and later still larger) doses given subcutaneously.

Amazingly, Dr Martin Henry Dawson's careful and cautious technique on that historical day are still followed to the letter by all well trained nurses and doctors....

October 16 1940 : ending the era of human-only progress and ushering in our era of bio-diverse cleverness

Purifying and then synthesizing such a comparatively small molecule like penicillin (produced after all by the primitive and simple basement slime) couldn't take very long, said an entire generation of chemists.

And then, and only then, with plenty of pure man-made penicillin at hand, would it finally be safe for clinicians to inject the blessed stuff into a dying patient's bloodstream.

But by mid October 1940, one clinician (Dr Martin Henry Dawson) had had more than enough of waiting for human chemists to put their synthetic money where their hubristic mouth was.

for even his highly talented co-worker, biochemist Dr Karl Meyer, had also failed to make much initial progress on determining the structure of the penicillin molecule.

And Meyer was miles and miles away from attempting to synthesize the stuff.

Dawson had two dying patients before him, for whom he sincerely believed penicillin was their only possible lifeline.

He knew they would need a great deal of clinical penicillin to be saved, but only a little penicillin was at hand.

But a little was better than nothing --- and even a token injection might raise their morale higher even if it did little to lower the microbe count inside their damaged heart valves.

The relatively small amounts of native penicillin that the tiny team at NYC's Columbia Presbyterian medical complex had grown so far had all been divided between Dawson's co-worker Gladys Hobby's microbiological tests and Meyer's (and his assistant Eleanor Chaffee's) chemical tests.

But in 1940, Henry Dawson had a much greater faith in the ability of (raw - impure - natural - native - crude) fungus-made penicillin to cure patients than any other doctor in the world.

Like many other infection experts around the world, he had read of Howard Florey's Oxford team's success with raw penicillin injections in safely curing many experimental infections in many different animals.

But all the other infection experts had read and remained unmoved .

Unmoved to to attempt injecting raw penicillin into humans, whether healthy volunteers or dying patients.

Not so Dawson - he had already had over a dozen years experience confirming that the supposedly simple and primitive microbes had at least as much native chemical ability under their tiny belts as had enormous conference halls filled with chemical PhDs.

His own colleagues had long grown weary of his endless informal lectures on the ability of tiny microbes to practise genetic/chemical engineering (bacterial transformation - HGT) at a skill level that the best human geneticists could only dream of.

The man was not just a bore, he was also 'letting down the side', at least as the Era of Human-Only Progress saw it.

For he had long claimed that the tiny, ancient and simple microbes were much, much cleverer than they were ever given credit for - cleverer than the most civilized of humanity, in many ways.

But he was harmless enough - for all this had only been talk so far.

But on this day - October 16th 1940 - Dawson decidedly 'went off the reservation' and crossed a deep cultural Rubicon.

For on this day, Dr Dawson finally gave his tiny chemists 'a fair go' when he injected SBE patients Aaron Alston and Charles Aronson with fungus-made penicillin.

Thus ending The Era of Human-Only Progress ---- and ushering in our present Era of Bio-Diverse Cleverness...

Age of Antibiotics' Patients Zero : Aaron Alston of St Nicholas Ave, Harlem and Charles Aronson of Vyse Ave, the Bronx

Thanks to the hard work of two relatives of these penicillin pioneers (Claude Jay for Aaron and Lisa Liel for Charles), these forgotten individuals can emerge from the shadows almost fully formed.

We don't know everything about them (we never do about anybody) but we sure know far more about them than we learned from the scanty evidence published up to now.

They were poor, came from unpopular minorities (one black, the other Jewish) and had a disease (SBE) then considered incurable and so they (and thousands like them) were written off by the Allied medical establishment as 'lives unworthy of wasting a lot of medical attention upon during a total war'.

A sentiment that was cheered upon by their counterparts in Germany, Russia and Japan during the same war - and for the same 'eugenic' reasons.

But one individual, Dr Martin Henry Dawson, gave up his own life to fight to keep them and people like them alive.

What good a military victory over Nazi medicine if the Nazi doctors won the moral war when the Allies agreed upon 'discarding the unfit in times of war and stress' ?

Aaron, the super athlete, might have been expected to do better fighting off his disease than the always sickly Charles but in fact he died in January 1941, just as Charles went home cured of his first bout of SBE ---thanks in part to his pioneering penicillin shots.

He had three more years of normal existence granted to him but got a second bout of SBE, which again he and penicillin beat.

But he also survived a severe stroke during the process which left him speechless and paralyzed .

Dawson's JAMA article of 1945 records "CA" as being transferred to an institution for chronic care on August 15 1944.

Since Dawson held a key post at Goldwater hospital, I had always guessed that is where Charles was sent.

Lisa send me Charles's 1951 death certificate which records that her relative went to Goldwater hospital on that exact same date and died there 7 years and a few months later.

Not the ending I - Charles - or anyone  - might have wished for ....

Of all the Charles Aronsons in America in 1940...

Regardless of their age or residence, the 1940 American national census only shows about 38 Charles Aronsons and a half dozen spelled with close variants ---- making the task of finding history's missing Patient Zero of the Age of Antibiotics much easier.


So if mystery patient "CA"*, aged 31 in April 1944 and around 27 in late 1940, was indeed Charles Aronson as Gladys Hobby and Louise Good affirmed in the 1980s, after re-examining contemporary hospital lab records, then he was born close upon either side of 1913.

And the evidence from the medical article mentioning his various experiences at that hospital, suggests he lived quite close to Manhattan's Columbia Presbyterian hospital between late 1940 and early 1946.

That suggests only one person - Charles Aronson of Vyse Avenue , a lifelong resident of New York, most all of it in the South Bronx area two miles from the hospital, born in mid June 1912.

True ,Charles N aronson was also born in the right time period, in March 1913, but in 1940 he was in the car centre of the world in Pontiac City Michigan.

Charles N Aronson's children told me he was healthy as a horse all his long life and that in late 1944 he was not in a home for chronic care with a paralyzing stroke as stated in the medical article on "CA" but rather was up and about busy inventing and patenting various bits of car parts.

A few other Charles Aronsons were born in years like 1906 or 1917 but were living in states hundreds of miles from NYC in 1940.

Hopefully in a few weeks or months, theNational Archives will be able to provide the draft registration card of CA - showing his ++++BRONX++++ home address......



* First that is together with Aaron Leroy Alston - both injected with penicillin, one right after the other on October 16th 1940 by Dr Martin Henry Dawson

October 16th 2015 'Red Letter Day' for Selective Service System AND Medicine !

Two extraordinary anniversaries -----connected by two extraordinary individuals

On October 16th 1940, 75 years ago this year, America's system of registering for selective service began - a process that continues to this very day.

On that very same day, 75 years ago, the Age of Antibiotics began.

Unlikely as it may seem, both events are intimately united in the persons of patients Aaron Alston and Charles Aronson.

For these two received history's first ever injections of penicillin at Columbia Presbyterian Hospital in New York on October 16 1940 ---- and then were immediately registered for selective service by a special team of hospital visiting registrars on that same day.

Both young men were suffering from subacute bacterial endocarditis.

The much dreaded "SBE" was then regarded as invariably fatal  --- the terminal disease that made Rheumatic Fever - not Polio - the leading killer of school age children throughout the western world.

Regardless of their likely fate in a few weeks or months, the selective service law was firm : both men must be registered ---- and so they were.

Born in 1910, Alston had been an almost Olympics class boxer and a winning track coach - he would have made an excellent leader of soldiers.

But neither he or the penicillin could fight off these strep bacteria and so he died in January 1941.

In his own quiet way, Aronson was also quite a fighter.

Born in 1912, he had already survived three frequently fatal childhood illnesses. He grew up to join the National Guard and hold down a full time job as a teletype operator at a newspaper.

And with the help of penicillin, he went on to survive not just one, but two bouts, of SBE. He then suffered a severe stroke that left him paralyzed and unable to speak.

But he bravely battled on for seven more years and then died in October 1951.

No important anniversaries should go un-noted, as these two anniversaries appear about to be, least of all when both anniversaries are united in the most extraordinary and unlikely of circumstances....

Un-Super Heroes, the Epilogue : Apollo Theatre , February 17th 1956

Scene 1, Act I of Un-Super Heroes opens on October 16th 1940 with the arrival of patient Charles Aronson at Columbia Presbyterian Hospital in New York City just as the last scene of the last Act (V) is August 15th 1944 with Charlie's departure from that same hospital.

But every drama deserves an epilogue and Un-Super Heroes's epilogue is set onstage at New York City's Apollo Theatre, just a mile from the Columbia Presbyterian Hospital, on the night of February 17th 1956.

Appearing as a headliner in New York City for the very first time is a Georgia-born black singer from a dead poor family , a singer born with a badly handicapped leg.

But if racism, poverty and his affliction have held him back , he could only echo the sentiments from one of the first of Dawson's SBE cures, Miriam Laskowitz .

Because, like her , regardless of what problems life has tossed him, his heart and lungs certainly weren't one of them.

No siree Bob - or should that be no siree
 "A-wop-bom-a-loo-mop-a-lomp-bom-bom!"

Because from the moment Little Richard opened his mouth, the whole world noticed that while almost all the original rock'n'roll greats ( white and black) were dead poor by American standards , their heart valves and lung capacity were definitely in great shape.

This then was penicillin's most lasting legacy.

Unlike Aaron Alston (also from Georgia like Little Richard, also poor talented and driven) Richard and other rock 'n' rollers did not have their talents die unused when some infectious disease tragically cut them down in young adulthood.

Dawson's cheap abundant penicillin-for-all benefited everyone for sure - but it benefited the poorest amongst us the most.

And they gave it back to us - in particular in voice, melody and dance.

I can't see Henry Dawson ever becoming a true fan of rock n roll - ragtime was the rock'n'roll of his teen years.

 But I feel sure even he'd smile a broad ironic grin to think of how much of that 'God-awful caterwauling noise 'was all down to his untiring efforts from 1940 to 1945 to secure some penicillin for the poor and the unwanted ....

'There's just something about a Mercury ' : how the potential of a young black man kickstarted penicillin and has benefitted ten billion of us ever since

Can we still - 75 years on - get some sense of the personality of the very first person in history to get an antibiotics injection ?

Fortunately , yes.

But why then should we even care ?

Because, children , just because.

Because the normally reserved doctor who kickstarted natural lifesaving penicillin-for-all (the medical approach that has benefited about ten billion of us since 1940) personally wrote and told Nobel winning Ernst Chain that this patient's personality and potential had directly inspired him to take up his penicillin crusade.

When the personality of a young black man inspired medicine's biggest ever paradigm shift, an event that saved my life and that of many in my family, of course I want to know all I can about this wonderful person.

And if you have ever had a family member saved by antibiotics and if you have even an ounce of gratitude within you, so should you.

So here is a long "letter to the editor" that A. (Aaron) Leroy Alston wrote , addressed to the black-oriented New York Age newspaper in early April 1939.

That is just 18 months before he received that historic first ever needle.

And it allows us to learn something of the patient who inspired a doctor to change our whole world for the better , forever .

Words of first patient in history to get an antibiotics injection

Aaron, a young black man with a high school graduation certificate , held a good day job in an insurance company at the height of the Great Depression.

This is quite impressive because the Depression was a tragic event for most Americans but certainly hit black Harlem extra extra hard.

He was also a winning track star who then founded the Mercury Athletic Club.

The club, with him as coach, manager, pr rep and fundraiser , focused on seeing that Harlem's black female runners finally got a chance to compete in the big races.

They did very well, as he says in this letter to the editor - for the first time black girls were being judged as the best runners in America in various categories.

Who knows what further good young Aaron might have done if only Alexander Fleming had tried harder, earlier, to see to it that penicillin become a real lifesaver.

True, (Martin) Henry Dawson in October 1940 did kickstart the process to make penicillin into a cheap abundant lifesaver that was available to all .

But though Dawson was inspired to do so by seeing all of young Alston's great potential going with him if he should die,  Dawson had made too little penicillin - at that time - to save Aaron.

So young Aaron died. But he was not a victim or a loser.

He had already done a lot.

And I sincerely believe that for all the good he might have gone on to do over a long life, if he hadn't contracted invariably fatal SBE endocarditis, it would never have matched what he did do as a dying patient.

For when his buoyant-personality-in-the-face-of-imminent-death met a doctor looking for a way to help retain social values in the middle of a big war, our whole world started to change for the better.

Who among us - including the fictional trio of Anne of Green Gables, Pollyanna and Rebecca of Sunnybrook Farm - can claim that great honour ?

Meet the "GOTHAM SEVEN"

Their leader, Dr Henry Dawson, dying of Myasthenia Gravis (MG) with deadly bulbar nerve involvement.

By the end , his MG crisis were ever more frequent and he was reduced to working out of a wheelchair, with oxygen assist.

WWI poison gas and too much time in damp trenches hadn't helped his lungs now threatened by bulbar nerve failings.

His foot and shoulder had also been severely wounded in the war, resulting in months spent in hospitals recovering.

His wife and helpmate, Marjorie Granger Dawson, had been born with congenital hip problems and no amount of operations had helped - she walked , but with a cane.

His clinical assistant , Thomas H Hunter. Polio had left him with two legs paralyzed so he got about with two crutches.

Former Dawson patient (and Dawson's great behind-the-scenes influence within the powerful WPB ) , financier Floyd Odlum.

The Warren Buffett of his age, he was crippled by rheumatoid arthritis while stressing about American unpreparedness for total war.

He was wracked with pain for the rest of his life and only really comfortable submersed in a warm water swimming pool.

Another former Dawson patient, Dr Dante Colitti

Years spent in hospital while doctors struggled to save his life from TB of the spine left him determined to become a surgeon despite his arthritis of the spine.

A condition which left him a hunchback and required him to use crutches.

The medical establishment rejected his services - partly because he was also catholic and Italian-American.

When he saw his chance he delighted in emulating Dawson , by tweaking the noses of the medically powerfuls by getting scarce penicillin for a dying baby via an appeal to the Hearst newspaper empire.

Miss H : Dawson's first SBE patient in which is can be said for sure that his penicillin alone saved her life.

But SBE casts its net wide and with her , it also damaged her uterus so badly she couldn't have children and left her blind in one eye. But she hung on, despite all the new operations and hospital stays, and thrived.

Her continued survival was crucial to answering the many doubters of Dawson's use of precious penicillin on the useless SBE patients, in the critical period between the Fall of 1942 and the Fall of 1945.

Charlie Aronson, along with Aaron Alston, was the first person to ever get a penicillin shot. Dawson's historical injections couldn't have hurt, because Charlie amazingly survived the then almost invariably fatal SBE.

He got a second bout of SBE and more Dawson penicillin again saved his life - but SBE also gave him a life threatening major stroke that left him permanently paralyzed in speech and body and in a wheelchair.

He survived and thrived - it was but the latest in a life long battle with a half dozen diseases that should have killed him.

As far as we know , he survived SBE - thanks in part to his historic first ever penicillin injection - from October 1940 till at least the end of December 1948.

(My current best guess is that he lived at least until 1955.)

His continued survival again stifled the many doubters to Dawson's SBE efforts.

In the parlance of the day, all seven were 4F --- in fact, the 4F of the 4F , useless, unfit, useless mouths.

But these seven , the Gotham Seven, were the ones who fought off their own Allied government and their own physical weaknesses to rescue natural lifesaving penicillin and set it free for all.

Honour their names : un-super heroes indeed....

A. Leroy Alston , noted New York black athlete , was first person in history to get a shot of penicillin - Oct 16 1940 Manhattan

Penicillin histories record the first person ever to receive an antibiotics shot only as Aaron Alston and that is about it.

Aaron himself (along with his family and friends) called himself Leroy.

He signed himself A. Leroy Alston whenever he appeared in the newspapers (which he did fairly frequently) in his role as an outstanding amateur athlete and athletic coach.

His parents Louise (Glaze) Alston and William (known as Stock) Alston came from Georgia and arrived in Harlem in 1923 , with their only child Leroy actually being born in South Carolina in 1910.

His family ran a restaurant on 8th Avenue in Harlem and lived in the Sugar Hill district of Harlem.

He finished high school and worked as a file clerk in a fire insurance company.

On the 1930 census he was married to Charlotte L Alston , about his same age, but she had died by time of the 1940 census - as had his father.

Leroy's real passion was for athletics - a  winning runner at major matches and great in baseball, he was best known for coaching a girls' track and field team ,the Mercury ACs - in fact he fundraised for them and promoted them non stop.

No wonder his doctor Martin Henry Dawson described him  to Ernst Chain, as a patient "in whom he was particularly interested "...

75th Anniversary of First Penicillin Shot, NY Oct 16 1940

Next October 2015 will see the 75th Anniversary of the first ever shot of Antibiotics - a historical event that took place at Manhattan's Columbia-Presbyterian Medical Centre on October 16th 1940.

It marks our very last chance to honour  these medical pioneers while some of them are still alive.

Some hometowns  - and not just in the Third World - did not see their first use of antibiotics for five to ten years after Manhattan did .

Their chances of having those pioneering medical personnel and the often very young pioneering patients still with us is potentially great.

But in the case of the very first case in Manhattan , we can only invite the surviving children and grandchildren of the small medical team and the first two patients to mark the 75th Anniversary of the birthing of our Age of Antibiotics .

Those two were young men dying of then invariably fatal SBE - the endocarditis that is the real killer in cases of Rheumatic Fever - one a 30 year old black from St Nicholas Avenue in Harlem , Aaron Alston, and the other , Charles Aronson , probably a 27 year old Jewish boy from Vyse Avenue in the Bronx.

But that won't happen without help from all of us to find those first medical staff and first patients and families members - in your hometown as well as in New York City ....

Why Charlie ? Why Miss "H" ?

Between September 1940 and April 1945, pioneering penicillin doctor Martin Henry Dawson treated about three dozen patients with subacute bacterial endocarditis (SBE) or acute bacterial endocarditis (ABE).

So out of those three dozen patients , why on earth did I decide to focus on just two - one young man (Charles Aronson) and one young woman (Miss H H) ?

One reason was to simply add continuity and coherence to my narrative, particularly my libretto narrative.

Charlie was there, on-site, in Dawson's ward at the very beginning and at the very end of the narrative arc - something you just invent in a work of fiction but something you rarely find in real life.

(Charlie had the extremely rare good luck to survive his first bout of SBE and the extremely bad luck to get a second bout of SBE and then to survive a severe stroke while recovering from that second bout .)

The arrival of Miss "H" provoked the crucial turning point in the narrative arc and her prolonged recovery from the side effects of her SBE ensured she was in many scenes - including the climatic one , along with Charlie.

Again a real life boon rarely granted the author of narrative non-fiction !

But my main reason for including these two in Dawson's team of seven key 'unfits' is because I sense these two , out of all the three dozen patients, were more 'actors' than 'acted upon' (which is the normal role for patients in such doctor-oriented stories).

The first period of extensive penicillium growing and penicillin extraction was originally planned to occur at the end of the first term (December) at Dawson and co-team leader Meyer's medical school.

But Dawson suddenly decided to give the first (tiny) historic injections of penicillin just 5 weeks into the 16 week process - seemingly right after Charlie unexpectedly joined the team's first SBE patient, Aaron Alston.

Dawson did write Ernst Chain at that time that he had a patient of whom he was unusually interested in - and admittedly that could have been either Aaron or Charlie.

But Charlie, he later noted, had an unusually complicated medical history - all revolving around surviving repeated brushes of death with oral commensal strep.

And nothing in life - nothing - interested Dawson more than oral commensal strep .

And Charlie was a repeated 'survivor' , probably with the characteristic survivor's buoyancy.

This alone might have inspired Dawson onward to also do his very best.

Much the same for Miss "H" - after all, for her, the very honest and modest Dawson 'stole' incredibly scarce government-controlled penicillin in the middle of an all-out Total War  !

Her earlier medical history indicated she had survived a life-threatening bout of Rheumatic Fever with 'endocarditis' involvement (probably actually severe pancarditis) .

 She went on to survive her SBE thanks to Dawson's penicillin (the first case in history ever cured by penicillin) and then to endure years of serious infections caused by infected matter from her damaged heart valve infecting other parts of her body - she lost one eye and her womb in the process.

But like Charlie, she survived them all - she was a born survivor , probably with a similar characteristic buoyancy.

So : two real-life 'larger-than-life' characters just crying out to be portrayed on stage by first class actors yearning to stretch their craft .

What's there not to like ???!!!!

Aaron Alston - Antibiotics pioneer on '40 draft count but not on '40 census ?

In the Spring of 1941 *, the US Census discovered a major embarrassment : it counted far fewer young black men in April 1940 than did the draft registration process in October of that same year, only five months later.

Three percent of draft age men were missed by the census overall, but a whooping 13% of blacks - an even higher difference in the correct count in inner city places like Harlem New York.

This (fiscally important) undercounting of the poor and minorities has never really stopped and probably never will --- not if Republican congressmen have any say in the matter.

But it might mean a little bit of information on Aaron Alston may still be found found on the (sealed) US draft registration card made out for Alston October 16 1940 at the Columbia-Presbyterian Medical Center , the same day he was becoming one of history's first antibiotics patients.
Because there is no Aaron Alston on the April 1940 census in the state of New York or in states nearby to New York City like Connecticut, New Jersey or Pennsylvania .

I have speculated he may have moved to New York from rural America seeking work between April and October that year but the possibility he was already in the New York City area near the hospital and simply uncounted in the census can't be discounted.

In the case of this truly historical event - perhaps that draft registration record might even be unsealed - who knows ?

* Daniel O. Price, "A Check on Under-Enumeration in the 1940 Census" American Sociological Review, Volume 12, Issue 1 (Feb., 1947), pp.44-49

Aaron Alston , penicillin's first SBE patient but second to get the historical injection

The known published facts are few

All the contemporary (1945 era) newspaper and book accounts - written by (or coming second hand from) participant eyewitnesses to the events themselves - make it clear that Martin Henry Dawson's first SBE/penicillin patient was a "negro" "man".

And that his name was"Aaron Alston" and that he subsequently "died".

The available record of the amounts and dates that Aaron received Dawson's penicillin - as published by key Dawson team member Dr Gladys L Hobby in her 1985 book on penicillin , Penicillin : Meeting the Challenge , ceases near the end of January 1941.

And that is all the published accounts show.

But now for new research and reasoned suppositions...

We can say that 1940s medical statistics indicate that Alston was a more likely than not a young adult when he entered the hospital with SBE .

It is clear from the census that the names Aaron and Alston is a combination found in a fair number of men in America in the first half century of the 29th century.

However , the censuses generally indicates they are usually negro and that their residences seem centred in the South - from rural Carolina into urban black centres like Washington and Baltimore.

But in the critical 1940 census , there is no Aaron Alston recorded in New York City or in nearby New Jersey and Connecticut.

Now the first SBE patients that Dawson dealt with in the public wards of his upper Manhattan Columbia University Presbyterian Hospital were simply there because they were poor and his hospital happened to be close to where their family lived or close to where they lived when they took ill.

They were not drawn there from great distances because Dawson was then a famous and successful expert in this nearly 100% invariably fatal disease.

Far from it , he hadn't in fact handled any SBE cases up to then as the lead doctor.

Alston almost certainly had to be residing within a three or four miles circle of the Presbyterian hospital, at most , at the time he took ill. But the census does not show this.

He may have moved to New York City after April 1940 and before September 1940 : because southern blacks were still coming north to the unofficial American black capital of Harlem , though there was rarely gold for them at the end of its tattered rainbow.

Harlem is well within the catchment area for the Presbyterian's public wards.

We seemed to have failed to find out anything more about Mr Alston.

But as it happens, the New York City individual death records up to 1948 have been hand indexed on computer by many volunteers and made available via Ancestry.com.

They show an Aaron Alston , born about 1911 , (that is about age 29 on date of his admission to the hospital in September-October 1940) has having died on Jan 25th 1941 in Manhattan.

I am not sure that the original  death record will reveal more more - but perhaps a last address in New York and the name of next of kin and their home town , but I feel 100% certain this is our Mr Alston.

All we have really confirmed so far is that he was indeed a young man at time of his admission , as expected.

Why first patient but second to get the historic penicillin injection

Now while I am certain that Mr Alston was first SBE patient Dawson intended to treat with penicillin, I think he got it moments after Charles Aronson , the other SBE patient to get the historic penicillin injections on October 16th 1940.

Dawson's first major paper on penicillin and SBE was significantly the first penicillin paper not written by him with the help of the very reticent (as he himself was !) Dr Gladys Hobby, his lab chief.

Co-written instead with young Dr Thomas H Hunter, it positively gushes - for Dawson anyway - in giving forth the ages, initials of their name, gender, ethnicity,  dates of treatment, medical condition etc of all the SBE patients that Dawson had treated.

This was a style that Dawson had never shown before in 20 years of writing many, many medical articles.

Some doctors ("clinicians") simply tend to write articles that minutely detail the very 'grain' of  one (person's) case - while others ("researchers") prefer to report on the general conclusions drawn from treating one hundred similar cases.

(Both are valuable to doctors and scientists - but biographers won't be human if they didn't prefer the intimate details of the first type of articles !)

Dawson gets a chance in mid April 1944 to treat Charles Aronson a second time with penicillin for SBE .

This was because the little penicillin Charles had gotten in October 1940 had helped him survive his first bout of SBE.

He thus became that rare successful SBE case (about one in a hundred) that did so , back then.

Dawson indicates  in 1945 , that Charles had first entered the Presbyterian three and a half years earlier - ie mid October 1940 , confirming the common assumption that he was a very late addition to Dawson's Penicillin SBE program.

(Dawson knew he had too little penicillin to even treat Alston adequately, but he kind-heartedly treated both.

He was hoping perhaps that any small sign of a clinical response from either one of them might move Big Pharma to step up to the plate and mass produce the stuff --- for Aaron, Charlie and everyone else.)

Literally : the last shall be first 

But did Dawson really add Charlie at the last minute out of kind-heartedness alone ?

I believe the real reason was because Charlie was such a late addition to his ward's SBE patients.

When a new patient arrived with suspected SBE - a relatively slow killer, first a number of blood tests over a number of days must show the continued and not merely transitory presence of green strep in the blood stream to match all the other classic clinical signs of SBE,.

Then the ethical response is to immediately start treatment with the newest miracle drug , sulfa, and pray.

This is what happened to Aaron, who had been in the ward about a month when he first got his penicillin.

But because Charlie was such a late addition, there hadn't been time to start treatment with sulfa drugs .

So if Charles was treated with penicillin alone and did show a clinical improvement, Dawson's sulfa worshipping naysayers (and their lineup began around the block) could not say it was all due to their established sulfa , not his new penicillin.

(Remember that a lot of middle-aged doctors , the same age as Dawson , had first made their mark as early sulfa drug pioneers - any new miracle drug meant their acclaim was over. )

Behind the polite rancour of academic/scientific 'critiques' is often a lot of half-hidden ego and income concerns.

Dawson recalled, in his 1945 article , that the 1940 Charles was treated with penicillin on October 16 and 17th and then immediately (first) "started" on sulfa on October 22 and that he responded so well that he was released in December and was illness free for three plus years.

Ethically, Dawson would never have wasted half of his tiny amount of penicillin he intended for Aaron on Charles --- if he was already responding well to sulfa.

I think the reason it became so urgent to treat Aaron in mid-October (well in advance of the Dawson team's own original timetable for starting clinical trials) was because he had already been treated with sulfa and it had failed.

And maybe even made him extremely sick  because allergies to sulfa are common and serious.

But treating Aaron alone risked having any penicillin success disputed by the pro-sulfa lobby and this would only forestall drug company involvement - hurting Aaron as well as all others.

Hence Charlie not only getting treatment but getting treated ahead of Aaron , if only by moments.

Ask anyone : nothing starts off a (soon to be citation classic) medical article quite like an opening sentence like this one ---

"The first patient  ever treated with systemic penicillin had (then invariably fatal) SBE , but had not yet had time to start a sulfa treatment, however he responded so well to the penicillin that he has now been home fully recovered for over six months months."

In fact Dawson saw no clinical response at all between cases of endocarditis and penicillin for one and a half long years and he didn't save anyone with the disease purely on penicillin alone until two years later.

But Charles's recovery might have been helped by the morale uplifting affect of simply knowing that he was Patient One of a touted new Miracle drug .

I can only hope that my research efforts eventually help Aaron Alston's relatives to gain some comfort from his short life.

They will learn that he helped bring penicillin into this world and that while it didn't help him personally, it has directly and indirectly helped ten billion of us in the seventy five years since he first received it.....

WWII: the horrific medical 'Triaging' of New York Jews and Blacks

Here is a challenge I throw out to New York City's many amateur historians and genealogical detectives : find out more about the young New Yorker who was the first person ever in the world to be treated - successfully - with penicillin-the-antibiotic.

Particularly if you interested in uncovering more about the harsh wartime treatment afforded many first generation inner city New York Blacks and  Jews.

So, again, a challenge : find out more about PATIENT ONE , the young New Yorker(s)  who first introduced the Age of Antibiotics against fierce resistance from the medical establishment.

Here's a little what we already know for certain (past and future posts on this blog will add more details : the keywords to search are Charles Aronson , Aaron Alston and (Martin) Henry Dawson.)

Patient One , A and B

Actually, two young New Yorkers were given a needle of penicillin by Doctor Martin Henry Dawson on that same history-making day (October 16th 1940) at the famed Columbia Prebyterian Medical Centre : a young Black and a young  Jew, both probably poor.

Its quite a story from how these two young ,poor, men from these ethnicities, traditionally regarded as 'last' , came to be 'first' ever in the world to receive the miracle of antibiotics.

Both young men were dying of then common dreaded and 99% invariably fatal SBE (Subacute Bacterial Endocarditis), a disease that hits the heart valves.

Heart valves damaged earlier by RF (Rheumatic Fever).

Working in tandem, these two related diseases were the most common way for school age children to die in the 20th Century , until about 1960.

The Polio of the Poor

RF was "The Polio of the Poor", because just as the much less common Polio was highly selective and tended to hit the children of well to do WASPs in the leafy suburbs, RF tended to hit  hardest among the poor children of inner city immigrants and minorities.

Unless you are wilfully naive , you probably have guessed by now why you have heard so very much more about relatively uncommon serious cases of Polio than about the much more common - and commonly fatal - RF & SBE !

There is no doubt at all that first patient to be selected for this experimental treatment was a young black man, Aaron Alston.

Penicillin had been discovered exactly 12 years earlier and a little ( very primitive work) had been even been published on growing it , but it remained basically unknown and unused in 1940.

So Dawson and his co-workers ( Meyer, Hobby and Chaffee) were still at the square one of square one, a few weeks into their first attempt to try and grow the mold in their hospital lab,  when a seriously ill Aaron Alston arrived on a ward that Dawson 'attended' (had some limited medical authority over).

It had not been expected that they would have enough penicillin made, purified and tested for clinical trials for another four months.

But Dawson's heart went out to Alston, because Dawson reasoned, based on what little he knew of penicillin, that  penicillin might finally conquer SBE.

(A disease by the way he had never published even one word on - he was in fact hired to work in an area that was very neglected and directed to leave a well researched disease like SBE to the time- proven experts.)

The disease then (and perhaps still now) was regarded as the Mount Everest of all infectious disease, the Gold Standard test of any new anti-bacterial medication.

Delay meant Death

He decided to ignore laborious hospital protocols for pre-testing new drug treatments : Alston would die before he got this one last shot at life , if they choose to wait four further months  down the road.

Dawson would first test penicillin's potential toxicity (of which there was , to put it extremely mildly, absolutely no evidence of, judging by lots of  previously published work on small animals and human blood cells) on himself.

Then he'd give a little at a time to Alston, slowly and cautiously.

The team was only making very little amounts of a very weak penicillin at that time, so this was really just making a virtue of necessity !

How did Dawson know that Alston was so rapidly dying, that haste was imperative ?

There is no direct evidence but the indirect evidence is compelling, I believe, that Alston had already received the conventional treatment for SBE in 1940, prolonged and massive treatments by the new miracle drugs, the sulfas.

Most SBE patients in 1940 got at least a brief improvement with sulfa drugs.

 But the bacteria fought back and the same miserable one percent survived with sulfa treatments (only to die when the disease returned a year or two later)...... as with those receiving no treatment what so ever.

However some patients got no relief from sulfa - the number of bacteria colonies in the blood went up (and not down) after treatment and the doctors then knew these patients' particular strain of oral strep bacteria in their heart valves were particularly resistant to the sulfa drugs and that death would be swift and certain.

 I believe Alston was one of these patients and this is why Dawson decided to go to clinical trial four months early, and after only five weeks from first even learning of what very little was known about penicillin.

And why the other more senior doctors let him try his penicillin on the clearly dying Alston.

Since massive and prolonged amounts of sulfa had failed to kill off all the heart valve bacteria, it seemed pointless to hope that a very little bit of very weak penicillin would do the trick.

But it was worth the effort to Dawson and the others doctors really couldn't see why he couldn't at least try, this once - but only in his own spare time, when he won't be neglecting his own proper duties.

 Dawson's ideas on the immense worth of penicillin were regarded as madness by his hospital colleagues and he really needed to show even a small , if temporary, reduction in the number of bloodstream bacterial colonies if he hoped to receive further help, not further hinderance, from his hospital chiefs.

In fact, it took three more years before any more than a few dozen doctors in the whole world thought that penicillin was worth bothering about.

 Need I add, three more war years, filled with additional millions  of patients dying from war-related bacterial infections ?

For the fact is that for the first fifteen long years, penicillin's worst enemy wasn't bacteria but rather doctors themselves.

Antibiotics arrives, despite doctors' best efforts

By and large, the Age of Antibiotics arrived in this world despite the best efforts of doctors, not because of their efforts.

Hence Dawson's decision to use all of a tiny amount of a weak solution, pushed into just one patient, in hopes of seeing even a hint of successful, if temporary, results.

 A chance to keep his hospital bosses off his back and a chance they'd let him continue his massive mold-growing efforts inside their precious neat and tidy ultra-modern medical centre.

That first needle offered up a potential lifeline to a young dying black man.... and a potential lifeline to billions of future patients.

Enter Charles Aronson

But then Dawson deliberately chose to blow it - or so it seemed.

Another dying young man, a  twenty seven year old Jewish boy named Charles Aronson, arrived on the ward, days before Alston was to get all the meagre penicillin that had been hand-grown so far.

Spontaneously, Dawson added him to this first clinical trial, dividing the meagre lifeline into two thinner lifelines, like a latter day Solomon.

Why ? Why when this further weakened any slim hopes of observing a clinical response?

Several reasons.

Firstly, lots of test tube results had confirmed that penicillin, by weight, was thousands as times potent as the sulfas.

This, despite the fact that their 1940 homegrown 'penicillin' was actually 99.5% dross -- but luckily they'd didn't know this .

Ordinarily, even their small amounts of weak penicillin, even divided in two, would have given clear signs of response, in almost any other bacterial disease.

Except SBE : its unique combo of 'gotchas' rightly made it the Mount Everest of infection, and thought Dawson ultimately did cure SBE with penicillin, he did so only after rolling many massive stones of Sisyphus  penicillin up that Mount.

But again they didn't know this at the time.

Secondly, Aronson had an uniquely complicated, and sad, medical history revolving around repeated attacks from all kinds of seemingly different strep bacteria diseases.

To Dawson, 'seeming different' was the key phrase.

For Dawson's personal/private research interest was in relating all the varied survival techniques he saw as shared by the strep bacteria that co-exist with us.

They live in our mouths, throats and nose much of the time and very occasionally causing serious disease by the ways some of our bodies choose to respond to those sophisticated survival techniques.

But I think this was a minor part of what got Dawson to add Aronson to that first clinical trial.

Dawson hated Triage

Because one of the abiding qualities of Dawson was his lifelong hatred of Triage , which unfortunately happened to be the chief and defining characteristic of the era he lived in, The Era of Modernity.

Modernity was all about, always, the dividing the world into two piles ---- those humans, beings and places worthy of continued life and succour and those unworthy of further life and support : in a word, Triage.

Think of all those medical doctors in jack boots, standing at the railway siding in places like Auschwitz, deciding in an instant if you were to die quickly in a shower or die slowly working too hard for too little food : Triage.

Triage had hit Dawson's hospital that Fall of 1940 : orders had gone out to focus resources on the diseases that affect front line 1A troops and to downplay devoting resources on diseases that only affect the useless 4Fs.

A wonderful time for medical political conservatives to gleefully call for a massive rollback of 1930s efforts to reduce the death rates among the poor, the minorities and the immigrants ("Social" Medicine) , under the guise that all resources were needed to keep our "boys" alive at the up-coming frontline : "War" Medicine.

Now if there ever was a Poster Child of a disease the war medicine hawks didn't want to treat, it was SBE and here is why.

Unlike Polio ( whose research efforts expanded during the war years) , the conservatives' own kids weren't likely to get RF and SBE.

And unfortunately both diseases were different from many other potentially fatal diseases like smallpox where if you got it once and survived, it would never hit you again.

Even 'curing' a bout of RF and SBE left behind permanent damage which made it not just likely you'd be hit again with new bouts, but hit harder each time as your delicate heart valves further weakened.

These were progressive, re-occuring, infectious diseases with a strong component of deadly auto-immunity to add to the mix.

Any success with SBE was going to be long and expensive in hospital resources, leave the cured patient still unable to serve in the military and do anything very arduous in a war plant - and a year later they be back in hospital again with another potentially fatal bout.

Neglect them and let them die quickly and quietly at home, at least until this war is over,  was the Allied medical establishment's decision worldwide.

Since this also was the Nazis' line, Dawson doubted we would really 'win' a war against them by taking up their horrific tactics.

This is why he deliberately choose to begin the new Age of Antibiotics on October 16 1940,  the first registration day for the
first ever peacetime draft, a day devoted to seeking out and celebrating the 1A youth of America.

He would mark that historical date by instead seeking out and celebrating the 4Fs of the 4Fs of America, celebrating the worthiness of  the least of these.

Cynical, clinical, trials

Conventionally having two (or more) patients suffering from the same disease under your medical wing at the moment when you are about to begin a new form of medical treatment was considered a godsend.

One half would get the old treatment and the other half the new treatment.

Officially and publicly the doctor(s) claimed to agnostic between the virtues of both treatments but that was rarely really true for the first pioneering medical teams.

Inside the privacy of their mind and conscience, they really didn't think the older treatment worked or at least didn't work very well.

This is because a strong belief in the likely success of a new drug was needed before any doctor is willing to do the extremely arduous work of being the first to try out a totally new treatment.

If the disease being treated was acute and had a high fatality rate, the trial would mean some would die who could have been saved , by the time good results came in.

The discussion of the early mass clinical trials of sulfa for dangerous diseases like pneumonia make extremely disturbing reading 75 years later.

Blithely it is - briefly - noted that hundreds died in these various trials.

Hundreds who could have lived if these pioneering true believers in the virtues of sulfa had consistently given their (abundant) supplies to everyone they felt might be saved by it.

The tiny amounts moral dilemma

The worst moral dilemma for many initial trials is that only a tiny amount of a potentially life-saving drug for an acute (rapid) disease has been made - because making this new drug is still hard and expensive and the pharma firm is unwilling to scale up production before there are good signs it might work.

(One drug in a thousand survives the normally long, long expensive trek from the first look at it, to mass production and mass use.)

Such new life-saving drugs tend to go to specialists in the disease it is judged best suited for and these doctors frequently have many
rapidly dying patients at hand who might live if they get it.

The only moral, ethical, solution is to grit one's teeth, stop up your tears and resolve to divide the limited supply among the healthiest/youngest/smallest patients, hoping in this way to get a few successes that will spur on greater production of the drug.

A dozen small children might use the same weight of limited drug as one elderly , weak, fat, adult ---- and get better results.

But with this very biased success could come more of the drug, to then humanely treat all the dying without selecting one over another.

Carefully applied, triage can be highly moral.

But there didn't seem any reason, in advance, to pick one of these young men over the other for the initial clinical trial.

The war medicine hawks had already put the 1As in one worthy pile and the 4Fs in another unworthy pile and Dawson did not want to divide 4Fs into further piles based on no morally fit grounds.

Dawson refused to pick and choose between Alston and Aronson : both got a few days treatment until the supply ran out.

As it turned out, Alston later got a more extensive penicillin treatment but still died. Aronson got no further penicillin but lived - because his particular strain turned out to respond well to massive sulfa doses given for months at a time.

He didn't get another bout of SBE for about three and a half years - a true cure by even exacting standards.

This is why I believe, despite the fact that both men both penicillin within minutes of each other, Aronson got the first needle.

Alston , I  feel certain, had been getting sulfa for weeks but it is known that Aronson didn't get any sulfa until a few more weeks after his first penicillin treatment.

If Alston was in fact the very first patient ever treated by penicillin , any success with penicillin would be quickly and loudly explained away by the many, many pioneers of sulfa --- all claiming it was really due to the use of their drug.

But if the first ever patient was Aronson, any success penicillin had with him would be due to penicillin alone and hard to refute.

Convincing scientists - and their egos - is harder than making major scientific discoveries

The sad fact is that success in science is based on facts and evidence and is relatively easy to achieve.

But convincing other scientists of that success in science really means reminding a lot of awfully big egos that their particular hobby horse isn't the right path to success after all - an extremely difficult process.

Rhetoric, not facts, is key here ----- it might seem ridiculous to highlight the success of one patient given a medication just moments before another , but to truthfully claim that my medicine cured the very first patient it treated was (and is) a potent bragging point.

Dawson's ego was small but he was not naive : I believe he did treat Aronson first, if only by mere moments, to help him win his rhetorical battle with his doubting bosses.

Dawson was extremely modest and truthful : he only ever claimed that Aronson lived through this first bout of SBE due to sulfa, not his penicillin.

 (Though Dawson later did cure him of a second bout in 1944 with enough penicillin to make a real difference.)

William Osler's take on the whole affair ?

But perhaps you believe, along with the world famous Dr William Osler and a boatload of distinguished clinicians ever since, that bedside moral support is at least as important as drugs in helping a body fight off an infection.

Then you might be forgiven in thinking that the compassion Dawson displayed to Charles Aronson, in not 'triaging' him out of the penicillin trial, was at least as important as the tiny amount of penicillin he did receive, in allowing him to live.

One way to look at Dawson's early penicillin was regard it as only .56 of one percent pure.

But alternatively - particularly if, like me,  you are a big fan of New York born  Eddie Rabbit - you could regard it as being made of "nighty nine and forty four one hundreds percent pure love".

Then you can rationally believe that Dawson's penicillin did at least help cure an invariably fatal disease in the very first person in history ever to be treated by an antibiotic ....

On a day when most other youth got America's first peacetime draft card, Aaron & Charlie got History's first needle of antibiotics : Dies Mirabilis ,October 16 1940

When the possibility of  your nation joining a world wide war looms, getting your first ever draft registration card must feel just like getting the kiss of death, to a young man on the campus of Columbia University.

But when you are a young man on another part of Columbia's campus who has been written off  'as soon to die from an invariably fatal disease', getting instead History's first ever needle of antibiotics, must feel just like getting the kiss of life.

Hence the spooky Janus-like nature of Dies Mirabilis , October 16th 1940.....

The Cure for Auschwitz Disease : "Dawson's Crude" : .56% penicillin ...and 99 and 44/100ths pure love

Pray there comes a day when most premature deaths really are 'Acts of God', when even the best of money and the best of medical care could not result in a happy ending.

But until that happier day, most premature deaths in the world - in peace as in war - are 'Acts of Humanity' , or rather 'Acts of Lack of Humanity'.

Sins of Omission : premature death caused because the people dying are not judged (by others more fortunate) as worthy of devoting much money or effort towards saving.

In war, comparatively few people die as soldiers dying of mortal wounds gained in combat.

The Nazis' behavior provides a particularly clear example of this.

They fed and cared for  the captured POWs and enemy civilians of some nations (the Dutch for example) but for other (Russians and Poles for example) many or most of these people were shot after battle or left to starve and die of disease from lack of food, medical care and shelter.

The food and fuel saved as a result meant that no German citizen went hungry or cold.

The right kind of German civilian anyway.

Using the war as excuse, the Nazis killed many German civilians, those judged 'life unworthy of life' , to free up food and hospitals for other Germans.

In another well known example of  WWII's Sins of Omission, Winston Churchill ignored the pleas of his top British officials in India and let four million poor Bengali civilians needlessly starve to death in 1943-1944 ,rather than divert some food and some shipping from  Allied peoples he judged more worthy of receiving them.

Even the different death rates from wounds gained in combat  , among the so called "modern" nations engaged in World War Two is revealing.

The Americans and British generally devoted more resources to saving their wounded compared to the Germans, Japanese, Russians and Italians.

 As a result,more western Allied troops survived the same severity of wound as experienced by troops of these other nations.

'Of course', I hear you say, 'they were richer nations, it was easy for them !'

But no : they had a choice, because the extra money devoted to this extraordinary care of the wounded could have been allocated elsewhere: to more and better anti-tank artillery, for example.

An extraordinary effort to produce the best anti-tank artillery ever made was , in fact, probably the cheapest way for the Western Allies to have ended the war against Germany at least a year earlier than it did, saving millions of lives all around.

I raise the genuine issue of better earlier anti-tank artillery versus the best possible military health care to remind us that even total war still leaves us with genuine moral choices.

More Lancaster bombers versus more 17 pounder anti-tank guns versus raising everyone's morale by generously providing penicillin enough for all people were some of the choices - part political, part moral, part economical - that leaders had to make in WWII.

Making the wrong ones meant the war dragged on longer than it had to, costing more lives lost.

It is not enough to say Churchill won the war in 1945 ; better to ask, could he have won the war in 1943 ?

In 1940, Henry Dawson was battling a near universal mindset among the world's research-oriented doctors of that time : that a medical researcher's only task was to determine that disease A was caused by bug B and that bug B was killed by compound C.

Then, like sleeping under a bridge, the researchers considered that the cure for disease A was open to rich and poor alike : pay for three weeks of needles at $10 a shot: together with doctors fees, say $250 in total.

When the annual wages of the working poor, if they found work, was very lucky to be $750 in 1940, that was a cure well beyond their reach.

Besides the fact that their disease might be far harder to cure than that of someone well off, due to the cumulative affect of their lack of good nutritious food for years and years.

Or that fact that living, as they did, in poor and crowded housing, disease A was more likely to come back again, even after an impossibly expensive cure.

Now what if disease A is something one gets from having open wounds - such as the open wounds all civilian mothers have after childbirth, or the open wounds that soldiers get after exposure to shell fire in battle.

How do we judge western Allied governments unwilling to provide the only life saver for disease A , either to any civilian moms (except those personally known to lead disease A researchers) or to any soldiers with wounds so severe they will be discharged and pensioned off, if they live ?

And how do we judge these governments when at the same time, they are gladly willing to provide live-saving compound C  (totally free !) to men who had either very high and very low peacetime incomes, just as long as their war wounds (by sheer luck) are only moderately severe and they can be expected to return soon to combat duty ?

Is this attitude not different in kind from that of the Nazis, but merely different in degree ?

Dawson had no realistic expectations that a few small injections of a very crude penicillin powder, hastily made in a few weeks, would cure such an incurable invariably fatal disease as subacute bacterial endocarditis, (SBE), then as now the acid test of all infectious diseases.

His powder had only about 8 to 9 units of penicillin per mg in it ; ie it was only about .56% pure.

The rest (the remaining 99 and 44/100ths worth),was in many researchers' minds, "junk".

Rather as they later described most of our DNA : "junk".

I believe Dawson considered his little bit of brown powder to be .56% penicillin and 99.44% pure love.

99.44% pure care, concern, caring.

For Dawson was judging his attempt to save Aaron Alston and Charlie Aronson by a much different - and much more moral - acid test.

To Dawson, SBE in the Fall of 1940 was not the acid test of infectious disease, but rather the acid test of pernicious morality.

These SBE patients were be judged to be 1940 America's "4Fs of the 4Fs", suffering from the militarily most useless disease on earth and not worthy of wasting any precious medical resources upon.

Now a doctor named Francis Peabody that Dawson had hoped to train with (but who died of cancer before that could occur) had earlier and famously said that the care of the patient begins (only begins in fact ) if the doctor first cares about the patient.

A single doctor can't hope to directly save everyone dying in a big war.

But by setting a very public example about caring for the least of these, those judged "unworthy of life", even in the midst of a war , they can hope to begin to still the trigger fingers of those all too willing to kill prisoners  just because 'it is too much bother to bring them back to our own lines'.

Only when the world is willing to care about "useless" others, even in the midst of wars, can we expect to begin to see war deaths reduced to combat mortal wounds, and then to ultimately see lesser and shorter and less brutal wars.

Only in a world where ordinary people care about others judged "useless", can we expect to still the hand that dropped the pellets at Auschwitz .

Which is why I earnestly claim that Dawson's Crude was the best and only cure for the Auschwitz Disease ....

Penicillin's four most famous patients shouldn't have been PATIENTS... according to the research protocol

When anal-retentive children grow up, if indeed they ever grow up, they either became clients of Madame X the Dominatrix... or they become medical research scientists devoted to extremely strict and rigid clinical trials with firm protocols and hard-fast deadlines.

So it was with wartime penicillin and a group of such anally-oriented researchers swore to devote whatever scarce natural penicillin they could produce to test on cases of staph (and gas gangrene) infections.

After all, the various patented and chemically synthesized  sulfa drugs could be relied upon to look after the far more common and more deadly strep infections, couldn't they ?

Or maybe not.

Let us look at those famous four early cases.

By chronology , the first was Charles Aronson ,dying of SBE (subacute bacterial endocarditis) caused by strep viridans in October 1940.

Dr Henry Dawson gave him a tiny amount of penicillin (to boost his morale) and a whole lot of sulfa to help his body defences and he unexpectedly survived this invariably fatal disease.

Case One : success one.

(About his fellow SBE patient, Aaron Alston, little is known for certain,  only that he received the exactly same tiny dosage of penicillin as Aronson at first and later got some additional slightly larger doses of penicillin.

It is implied that he died of his disease early in 1941: but then this is also said to be true of Aronson and that claim is definitely wrong.)

Case Two.

That famous policeman dying from the prick of a rose : Albert Alexander of Oxford would have lived, should have lived, if only Howard Florey hadn't polished the apple so long testing penicillin on healthy animals (his forte) rather than on dying humans.

That and stopping the course of antibiotics too soon (today a widely known elementary error but something I can't really blame Florey's team for back in February 1941.)

Alexander had a mixed infection of strep and staph that had gradually consumed most of his face and was now threatening his brain. At the stage of his disease when he first met penicillin, conventional wisdom was that he was a definite goner.

 It was second miracle that he recovered from this --- until the penicillin needed to totally clear up his infection was given to someone else who were not dying of their infection.

Case Three : Anne Miller.

The OSRD/CMR and the NAS/COC (the medical war lords of Washington, to adapt Bruce Catton's famous phrase) had agreed, along with the only two (out of over 200) drug companies in America that agreed to join in their restrictive government effort on penicillin, that the first priority on investigating the healing powers of penicillin was to look at staph infections.

In addition the two drug companies, Merck and Squibb , felt would be at least mid-1942 before any of this government-sanctioned penicillin would be released for clinical trials.

But strings were pulled to save the live of Florey's best friend, John Fulton, a top member of America's medical research elite --- by claiming the badly needed penicillin was actually for his fellow patient Anne Miller, dying of strep infection after a miscarriage.

So in March 1942, her life, too, was saved, in a dramatic fashion and post-the-awkward-fact that this totally broke all the agreed-upon protocols, the OSRD and NAS began touted Miller as the first patient treated in America.

 (Obviously not true, but "embedded historians", ie historians who do most of their research in the lush gardens of the self-selected "official" archives of the OSRD and NAS, have generally fallen for this hook and sinker.)

Case Four : Harry Lambert.

Lambert was an employee of Fleming Brothers, a very successful optical wholesale firm run by Alexander Fleming's family.

When his strep infection wasn't helped by sulfa, Alexander was pressured by his family to try some of his wonderful penicillin on the case.

Awkward that : cause Fleming claimed he didn't have any and never did have any of his miracle drug.

Fact was, Fleming was still totally repugnant to putting his own "crude" penicillin into the temple of a human body. So he went cap in hand to Florey to get some "refined" penicillin.

Florey, to his credit, gave him as much as he had - pulled from experiments in purification and synthesis of penicillin.

(Florey's penicillin was still 75% junk, just as Fleming's penicillin was 99% junk , but it had been manipulated by a real live chemist, so that made it alright to put in a body !)

Lambert's life was saved, partly by Florey's penicillin and partially by Fleming's surgeon manque skill in injecting it into Lambert's spine.

As a result, Fleming overnight became a true believer in his own medicine's systemic healing powers ,14 years after he first discovered it.

Sulfa-resistant strep was a leading cause of death by 1942...

Four cases, among many, where the first wonder drug , the sulfa family of medicines, were not working and where only penicillin saved a life.

But still a great reluctance (except from Henry Dawson) to say this aloud in front of the customers : that a mold-medicine was beaten the pants off a man-made synthetic and was not merely a supplement to sulfa for frontline staph wounds, but an all-around better life-saver and needed to be mass produced, like yesterday.....

"Little Belgium" : Floor "G" Columbia Presbyterian Hospital , Oct 16th 1940 - Feb 4th 1945

"LITTLE BELGIUM"

On October 16th 1940, the first day of registration for America's WWII Draft, Belgium was well past defending from the Boche.

Like Czechoslavia, Poland, Denmark, the Netherlands, Luxenbourg and Norway, Belgium was one of many small nations of Europe that had already fallen to Nazi Germany, without America so much as putting up a squeak.

WWII was not like WWI - if the Great War had been dominated by Victoria sentimentalism - WWII was Victorian social darwinism's war : a cold, hard-faced, ruthless war.

No "poor bleeding Belgium" this time - no "poor bleeding Poland" either.

Belgium was not an area of vital political or economic interest to America and so 'sentiment be damned' : America was not about to waste money and lives defending the small and the weak on the basis of mere humanitarian sentiment : 'we're living in the Modern Age, not the Victorian Era'.

But Dr Martin Henry Dawson had earlier felt much differently.

As a very young man, he abandoned his promising university career to join up the same day (October 16th 1915) that he first read in the North American newspapers that Edith Cavell had been executed for aiding the Belgians.

That meant that today marked his 25th year in Medicine, because he had initially joined up for a year in the medical corps, despite being a non-medical student.

Then, later, as first an infantryman and then as an artilleryman, he had spent most of the rest of the war in and out of hospital because he had twice been seriously wounded and won the Military Cross with Citation for bravery for his efforts while wounded.

Now, giving up his established career and family in still neutral America to get a Canadian Medical Corps desk job in England (as a middle aged/ middlingly healthy bacteriologist that was all he could hope for) didn't seem to be much in the way of help for Belgium and all the other small poor weak people being stomped upon by the Mighty and the Powerful .

Besides, the poor and the weak here at home in America were once again be stomped upon by the Mighty and Powerful of their own nation using the pending threat of war as an excuse to do so.

"We can't afford to waste scarce medical resources on Nature's 4Fs : eugenics teaches us that we need to preserve our best and that means our 1A fighting men".

So the few timid attempts at what was then called Social Medicine were halted and the money re-directed into War Medicine : research on the unique problems and diseases of fighting a modern world-wide war.

Social Medicine had its origins in the ferment around the Great Depression and the New Deal .

It combined directing more money on traditional public health measures aimed at the poorest citizens together with discussions on how best to ensure working class and middle class people had insurance against major medical emergencies.

All the powerful - from the AMA leadership on down - saw this as a giant intellectual threat to individualism and unfettered business enterprise.

The universities, then Republican Party hotbeds, led the charge against Social Medicine : and Columbia University-Presbyterian Hospital loyally signed up in the Fall of 1940 : directing its School of Medicine to put more teaching dollars into War Medicine courses without offering any new dollars to pay for it.

Guess what was hinted could be usefully cut,  to pay for the new courses ?

So the dawn of October 16th 1940 and all eyes of the media were on Columbia University's two campuses on Manhattan.

Columbia  was widely seen as a bellweather on whether American students, who had earlier talked about refusing to fight anymore wars, would obey their elders and register for the Draft.

To ensure all did, the university closed the two campuses and cancelled all classes for the day. Almost all the students and professors of young enough age, did indeed march off obediently to register before the lights and motion cameras of the newsreel crews.

(Including undergrad Jack Kerouac, who took time off from hefting big mysterious blocks of something or other for Fermi and Szilard's Atomic Pile in the basement of the Physics building.)

On October 16th 1940 and until the Actual Belgium's total liberation on February 4th 1945, Floor G became a defacto "Little Belgium"

But in Dawson's tiny team on Floor G of the Presbyterian building , no member had to go register : two (Hobby and Chaffee) were the right age and health, but as women were not valued as potential draftees.

Karl Meyer, like Dawson, was a Great War veteran but was now overage : Dawson was not only overage, his war wounds made him even more unattractive, even as a potential volunteer recruit.

The team's two patients (Aronson and Alston) were young men of the right age, so had to be registered in theory , despite being universally regarded as terminally ill.

I think that the draft officials might well have regarded it as a waste of time and needlessly cruel to register the two clearly dying boys , only to send 4F notices to their grieving parents two months later.

But I suspect Dawson would have urged the draft officials to register the two lads, because he believed that hope - along with his untried penicillin - was the best possible cure for their "invariably fatal" SBE.

"Register the boys - please - because I intend to have them up and in fighting trim in no time !"

(Those would have to be words for the boys' ears only, because no army ever knowingly took anyone with damaged heart valves , "cured" or not.)

SBEs, to be brutally frank, were the world's 4Fs of the 4Fs, probably the first victims of any rollback of Social Medicine .

To start their cure on the very day that North America's eyes were all focussed on War medicine's much touted 1As , had to be Dawson's silent rebuke to a nation and a medical community eager to overlook the poor and weak , in Poland, in Belgium and at home.

Morever, Dawson was rebuking Big Pharma's focus on the big as well, because they saw no reason to help Dawson and his foolish crusade to inject crude natural penicillin into humans.

So his medicine was not made in any huge factory by man-made techniques, but produced by billions of tiny fungus factories at the bottom of a handful of flasks in Dawson's own lab.

Verily, the weak and the foolish would have to come to the aid of the small and the weak, if the Mighty and the Wise were unwilling.

So it was on Day One of the start of the Age of Antibiotics.

And as Dawson abruptly lifted the needle into the air before sinking it gently along the skin of the boys' arm, the Italian in us might have seen it as a medical "up yours !".

And looking back from almost 75 years later, would we be so wrong.....