"The 'Cillium is a Roan that's never been rid , though thousands of chemists once claimed they did "

The title is a snatch of a song about the penicillium chrysogenum , with apologies to Curley Fletcher and his rather better known tale of the Strawberry Roan that also was never successfully rode.

To justify the expense of the Manhattan Project , America's military research bosses at the OSRD saw to it that A-bombs were dropped on Hiroshima and Nagasaki and then credited (wrongly) with being the sole cause for ending WWII.

To justify all the OSRD money wasted on not synthesizing penicillin, particularly when their rival WPB-OPRD spent far less to quickly make natural penicillin a resounding success, the OSRD bosses faked a synthetic success (about penicillin) to release to the gullible scientific media.

du Vigneaud's synthetic success (read synthetic = fake)

For Vincent du Vigneaud's team at Cornell Medical in NYC did indeed produce a little biologically active penicillin in the course of their efforts to synthesize penicillin.

So thousands of the world's top chemists got to take a public bow for yet another signal triumph in modern - BIG - science's endless progress ever upward.

But privately most knew that du Vigneaud synthetic goal was towards a molecule shape that did not match the necessary shape of biologically-active natural penicillin.

So this tiny amount of real penicillin must have been an accidental impurity of a mis-conceived theoretical approach !

More than 85 years after it was discovered, chemists have still not commercially synthesized a better or cheaper base penicillin molecule than what the tiny weak fungi can do on its own ...

The STRAWBERRY ROAN of Synthetic Chemistry : natural un-patented lifesaving penicillin

A thousand chemists tried and a thousand chemists died (at least in academic embarrassment) failing to break natural penicillin's bouncing bronco at the height of WWII - when they really should have been doing something far more useful - like fighting Hitler , instead of restraining the natural miracle's ability to save lives....

Natural penicillin's unexpected triumph --- against Synthetics' 1939-1945 war against Nature

Big Science - Synthetic Science - had a lot of triumphs during WWII, the war that its promises , not Hitler's megalomania, actually started.

Synthetic Oil, Synthetic Rubber, Synthetic Silk, Synthetic Quinine , Synthetic Man , Synthetic Penicillin all sought to replace 'unreliable' natural products with new improved Man-perfected 'predictable' substitutes.

Synthetic Plutonium (sic) , Synthetic DDT, Synthetic Zyklon-B , Synthetic Freon, and Synthetic Napalm went one step further when Man was considered to have created new products that Nature could never have dreamed up.

Thank God for Nature then !

And as for Man-made predictability , it is worth recalling that human chemists only make a tiny minority of all chemical compounds.

Chemists usually stumble on a compound with useful properties and then go to work on replacing its side chains until even better properties emerge.

But so too the environment and biological beings do the same to the sidechains of Man-made chemical compounds such as Freon and DDT.

 In the process Nature created massive un-natural disasters Scientific Man could never have predicted precisely but human humility might have considered a distinct possibility .



The German chemical world's promise that in the very near future total synthetic autarky was possible allowed enough otherwise sensible adult Germans to go along with Hitler's megalomania talk of endless wars of conquest to get the whole ball of wax started.

Sensible adult Germans who should have personally remembered the failure of WWI's ersatz synthetics to feed and heat a starving , freezing nation under total blockade.

Auschwitz to help birth the Perfect Man  , Man-Made Man, Synthetic Man

During WWII, Germans killed tens of millions of Slavs, Jews, Romas and Aryan 'unfits' , all part of a huge (scientific) war within a smaller (military) war .

That scientific war , a deadly serious war that both proceeded and succeeded WWII's nominally important military war, sought to replace Nature's messy plenitude of many imperfect natural types with one Man-made perfect , perfectly static , type.

The synthesis-minded, Nature's breakers , were going to tame these unruly bucking natural broncos.

Just as the Victorian Era pornographers had virtually tamed similar bucking uppity feminist women with stirrups* in their texts and images.

(*Victorian male doctors read pornography as much as other Victorian men did and they later renamed the foot rests for their female patients as "stirrups".)

The stinky,slinky, slimy , constantly mutating fungal molds existing in an unstable, unpredictable world midway between the solid/dry and the wet/flowing , were a particular bete noire to Modern Man , as a glance at that era's most feared monsters ( H P Lovecraft anyone ?) will readily attest.

This is the real, if largely unconscious , reason why 1939-1945's synthetic chemists warred against the penicillium mold (and not the enemy) and why doctors of that period declined to use perfectly safe, effective natural penicillin to save the dying.

But the penicillium was (and remains) one bucking bronco these chemical breakers never could break.

Hitler and the synthetic chemists thought they were good - but then Hitler and the chemists had never tangled with the Strawberry Roan ...

Natural penicillin the Strawberry Roan : there ain't no chemist here all alive that can stay with that mold when it makes that... high dive"

Chemists versus the fungal Strawberry Roan

To the Big Scientists of the Modern Age , natural penicillin from the penicillium mold was like an old moth-eaten cayuse , an old strawberry roan , a has been and a never was .

They saw it as a living being easily broken at the chemical wheel - requiring only a little heat and pressure to make it reveal all of its secrets.

Then the chemists could patent improved analogues of natural penicillin and thus corner the financial market on this precious lifesaver.

But as Montana Slim (Wilf Carter) might have sung it - "There ain't no chemist here all alive that can stay with that mold when it makes that... high dive."

Eighty seven years after chemists first set to work to break the penicillium mold , it still rides the range free and unpatented.

"A true micro bucking bronco that's never been rid, though there's many a chemist that claims that he did...."